Job description: We are seeking a Bioinformatics Scientist to join our cross-functional team and provide advanced computational biology support to aid genetic-data-driven target discovery for male-pattern baldness. The successful candidate will use integrated approaches involving a variety of 'omics data to test and refine biological hypotheses in coordination with wet-lab and computational colleagues. Responsibilities: upstream processing of 'omics data (QC, normalization, exploratory data analysis). downstream interrogation of bulk, single-cell, and/or spatial transcriptomic data (e.g., differential gene expression analysis, gene set enrichment analysis, cell type annotation, cell trajectory analysis, cell-cell communication analysis). Additional responsibilities may include analysis of proteomics or other data modalities depending upon project needs. Applicants should be familiar with high-performance computing systems, shell scripting in a Linux environment, and have strong facility with R and/or Python, including relevant bioinformatics packages (e.g., Seurat, edger/lima). Those with experience integrating multi-modal data (e.g., scRNAseq + scATACseq, spatial RNAseq + spatial proteomics) are especially encouraged to apply. Requirements: PhD in Bioinformatics, Genetics, Molecular and Cellular Biology, or related field or MS with at least 6 years of experience. single-cell and/or spatial transcriptome QC and analysis (e.g., with Seurat or Scanpy). bulk RNAseq data processing and analysis. facility with R and/or Python for data exploration and statistical analysis. experience with high-performance computing (HPC) and job submission systems. Katalyst Healthcares and Life Sciences
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